Application of Metagenomic Next-Generation Sequencing in the Diagnosis of Infectious Keratitis

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left">Methods</td><td class="align_center">Sample case (<i>n</i>)</td><td class="align_center">Positive case (<i>n</i>)</td><td class="align_center">Positive rate (%)</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">SC</td><td class="align_center">281</td><td class="align_center">133</td><td class="align_center">47.3</td></tr><tr><td class="align_left">CM</td><td class="align_center">245</td><td class="align_center">111</td><td class="align_center">45.3</td></tr><tr><td class="align_left">mNGS</td><td class="align_center">124</td><td class="align_center">104</td><td class="align_center">83.9</td></tr><tr><td class="align_left">PS</td><td class="align_center">207</td><td class="align_center">40</td><td class="align_center">19.3</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>SC, secretion culture; CM: corneal laser confocal microscopy; PS: pathological section; mNGS, metagenomic next-generation sequencing.<br/></div></td></tr></table>

<div>Positive rate of the detection methods.</div>

Journal of Ophthalmology

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Table 3

Table 3: Application of Metagenomic Next-Generation Sequencing in the Diagnosis of Infectious Keratitis 